In the brain, oxytocin modulates stress, emotion, mood, social and feeding behavior and displays anti-stress, anxiolytic, pro-social, analgesic, and anti-depressive effects3,4,5. It is often called the « good mood hormone » or « love hormone ».
The biological action of oxytocin is mediated by a single type of OT receptor (OT-R) belonging to the G-protein coupled receptors6.
Based on various beneficial oxytocin functions, it is actively researched as an attractive pharmacological target, for instance for the treatment of major depression (ex. via intranasal spray delivery)7. Oxytocin appears promising for treatments concerning other psychopathologies such as autism and schizophrenia, Prader-Willi syndrome, or helping to quit smoking.
TargEDys’ discovery: the molecular mimicry of oxytocin by a synergy of two PreciBiomic strains.
L. gasseri and L. salivarius produce the two most effective peptides (EFTU and PGK) able to activate the OT-R expressed in the gut.
Thanks to this molecular mimicry, the proteins delivered by the strains connect to the oxytocin receptors.
The activation of the OT-R has been confirmed through preclinical study, validating the concept.
The mechanism of action has been validated in vivo through different stress and anxiety models used in supplemented mice compared to controls.
These models are commonly used in pharmacological laboratories to study the action of anxiolytic and anti-depression drugs. All antidepression and anxiolytic evaluation tests have shown a positive effect of the treatment on mice behavior.
Contact-us to see the detail of the preclinical studies, not published yet.
World Happiness Report (WHO 2021)