Ten years of research have allowed Sergueï Fetissov and Pierre Déchelotte, professors at the Faculty of Medecine / Pharmacy of Rouen, to find out bacteria within the enterobacteriacea familly, which are present in the microbiome, makes a protein (ClpB) mimicking the hormone of satiety (α - MSH).
After a meal, gut bacteria begins to produce this protein, which directly acts on existing receptors in the gut. But this protein also passes in the blood stream and acts on the satiety regulation centre in the brain. This discovery is the subject of a publication dated February 2016 in Cell Metabolism and co-authored by the research team.
This discovery suggests that this connection between the gut and the central regulator of appetite is a new physiological mechanism, allowing to propose a new model of regulation of the appetite published in Nature Reviews in September 2016.
Thanks to the discoveries of its founders, TargEDys is developping nutritional interventions and therapeutic products for the control of the appetite and thus of the body weight. The € 5.8 million fundraising achieved in 2016 by the Compagny will allow it to continue its research by entering into clinical trials in human.