Ten years of reasearch have allowed Sergueï Fetissov and Pierre Déchelotte, professors at the Faculty of Medecine / Pharmacy of Rouen, to find out bacteria within the enterobacteriacea family, wich are present in the microbiome, makes a protein (ClpB) mimicking the hormone of satiety (α - MSH).
After a meal, gut bacteria begin to produce this specific protein, which directly acts on existing receptors in the gut. But this protein also passes in the blood stream and acts on the satiety regulation center in the brain. This discovery is the subject of a publication dated February 2016 in Cell Metabolism and co-authored by the research team.
This discovery suggests that this connection between the gut and the central regulator of appetite is a new physiological mechanism, allowing to propose a new model of regulation of the appetite published in Nature Reviews in September 2016.